Organoids in Microgravity: Redefining Human Biology and Drug Discovery
Organoids in Orbit — How Microgravity Is Redefining Drug Discovery and Human Biology "Somewhere, something incredible is waiting to be known." — Carl Sagan What Are Organoids? Organoids are miniature, self-organized 3D tissue models derived from stem cells that replicate many of the structural and functional aspects of real human organs. They can be made from induced pluripotent stem cells (iPSCs) —cells reprogrammed from a patient’s skin or blood—which allows scientists to recreate an individual’s unique biology in the lab. Brain, liver, intestinal, kidney, and heart organoids are now routinely grown for studying diseases, testing drugs, and exploring development. Their strength lies in personalization: a brain organoid from a Parkinson’s patient carries that patient’s exact mutations, providing a living testbed for therapies. The Limits of Growing Organoids on Earth Despite their promise, organoids grown on Earth face significant limitations: Gravity-induced deformatio...